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2006 04 254-256
皮肤毒性检验中替代模型的研究进展和应用评价
基金项目(Foundation): 广东省科技计划项目(2005B32401010)
邮箱(Email):
DOI: 10.16421/j.cnki.1002-3127.2006.04.020
中文作者单位:

广东省检验检疫技术中心,广东省检验检疫技术中心 广东广州510623,广东广州510623

摘要(Abstract):

关键词(KeyWords): 替代方法;;皮肤毒性;;安全性评价
参考文献

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[3]Petersen AB,Wulf HC,Gniadecki R,et al.Dihydroxyacetone,the active browning ingredient in sunless tanning lotions,induces DNA damage,cell-cycle block and apoptosis incultured HaCaT keratinocytes.Mutat Res,2004,560:173-186.

[4]Jean S,Meo M,Sabatier AS,et al.Evaluation of sunscreenprotection in human melanocytes exposed to UVA or UVBirradiation using the alkaline comet assay.PhotochemPhotobiol,2001,74:417-423.

[5]Kim BH,Lee YS,Kang KS.The mechanism of retinol-inducedirritation and its application to anti-irritant development.ToxicolLett,2003,146:65-73.

[6]Verrier AC,Schmitt D,Staquet MJ.Fragrance and contactallergens in vitro modulate the HLA-DR and E-caderinexpression on human epidermal Langerhans cells.Int ArchAllergy Immunol,1999,120:56-62.

[7]Han HS,Kwon YJ,Park MS,et al.Efficacy validaiton ofsynthesized retinol derivatives In vitro:stability toxicity andactivity.Bioorg Med Chem,2003,11:3839-3845.

[8]Jirova D,Kejlova K,Brabec M,et al.The benefits of the 3T3URU test in the safety assessment of cosmetics:long-termexperience from pre-marketing testing in the Czech Republic.Toxicol Vitro,2003,17:791-796.

[9]Cotsarelis G,Kaur P,Dhouailly D,et al.Epithelial stem cells inthe skin:definition markers localization and functions.ExpDermatol,1999,8:80-88.

[10]Cario AM,Briganti S,Picardo M,et al.Epidermal reconstructs:a new tool to study topical and systemic photoprotectivemolecules.J Photochem Photobiol,2002,68:79-87.

[11]Liebsch M,Traue D,Barrabas C,et al.The ECVAMprevalidaiton study on the use of epiderm for skin corrosivitytesting.ATLA,2000,28:371-401.

[12]Bernard FX,Pedretti N,Rosdy M,et al.Comparison of geneexpression profiles in human keratinocyte mono-layer cultures,reconstituted epidermis and normal human skin;transcriptionaleffects of retinoid treatments in reconstituted human epidermis.Exp Dermatol,2002,11:59-74.

[13]Lotte C,Patouillet C,Zanini M,et al.Permeation and skinabsorption:reproducibility of various industrial reconstructedhuman skin models.Skin Pharmacol Appl Skin Physiol,2002,15:18-30.

[14]Bernard FX,Barrault C,Deguery A,et al.Development of ahighly sensitive phototoxicity assay using the reconstructedhuman epidermis SkinEthik.In alternatives to animal testingⅡ:proceedings of the second international scientificconference organised by the european cosmetic industry.Brussels,Belgium,1999,167-174.

[15]Rodriguez H,O′Connell C,Barker PE,et al.Measurement ofDNA biomarkers for the safety of tissue-engineered medicalproducts,using artificial skin as a model.Tissue Eng,2004,10:1332-1345.

[16]Schlotmann K,Kaeten M,Black AF,et al.Consmetic efficacyclaims in vitro using a three-dimensional human skin model.InJ Cosmet Sci,2001,23:309-318.

[17]Duval C,Schmidt R,Regnier M,et al.The use of reconstructedhuman skin to evaluate UV-induced modifications andsunscreen efficacy.Exp Dermatol,2003,2:64-70.

[18]程树军,黄锦桃,李海标.胚胎干细胞源性表皮干细胞在腹腔微环境中分化潜能的初步研究.中山大学学报(医学科学版),2004,25:204-207.

基本信息:

DOI:10.16421/j.cnki.1002-3127.2006.04.020

中图分类号:R-331

引用信息:

[1]程树军,焦红.皮肤毒性检验中替代模型的研究进展和应用评价[J].毒理学杂志,2006(04):254-256.DOI:10.16421/j.cnki.1002-3127.2006.04.020.

基金信息:

广东省科技计划项目(2005B32401010)

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