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<正>术后谵妄(postoperative delirium,POD)是一种以急性认知功能障碍为特征的术后并发症,在老年患者中发生率高达15%~50%,明显延长住院时间并增加死亡率[1-2]。异氟烷作为吸入麻醉剂,因其诱导迅速、血流动力学稳定等特点,广泛应用于心胸外科、神经外科及老年患者手术。有研究表明,异氟烷麻醉后POD发生率明显高于静脉麻醉(如丙泊酚),尤其在老年群体中[3]。尽管异氟烷麻醉机制已较明确,但其神经毒性及诱发POD的具体分子通路仍不清晰。
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基本信息:
DOI:10.16421/j.cnki.1002-3127.2025.05.005
中图分类号:R994.3
引用信息:
[1]刘杏,代志明,张元会.异氟烷诱发术后谵妄的分子机制:基于网络毒理学与核心靶点的分子对接分析[J].毒理学杂志,2025,39(05):376-380.DOI:10.16421/j.cnki.1002-3127.2025.05.005.
基金信息:
咸阳市重大科研项目(2023-ZD-KY-02); 咸阳市创新能力支撑计划(L2024-CXNL-KJRCTD-KJRC-0016)