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2023, 04, v.37 361-364+369
肺纤维化信号通路的研究进展
基金项目(Foundation): 山东省自然基金(ZR2020MH336,ZR2015HL099); 山东省中医药科技项目(2020M077); 山东省医药卫生发展计划项目(2019WS592); 潍坊市科学技术发展计划项目(2022GX010,2022GX015); 潍坊医学院公派出国(境)访学项目经费资助
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DOI: 10.16421/j.cnki.1002-3127.2023.04.007
摘要:

<正>肺纤维化(pulmonary fibrosis,PF)是一种原因未明的弥漫性纤维化疾病,主要表现为机体受刺激后激活炎症反应、氧化应激、上皮间充质转化(epithelial-mesenchymal transition,EMT)等多重途径,使上皮细胞受到破坏,异常的Ⅱ型肺泡上皮细胞、间充质干细胞等细胞释放促纤维化机制,形成纤维化微环境,激活受累的肺成纤维细胞,逐渐向肌成纤维细胞转化,引起纤维化介质和细胞外基质(extracellular matrix,ECM)生成进一步加重,逐步形成PF[1]

Abstract:

KeyWords:
参考文献

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基本信息:

DOI:10.16421/j.cnki.1002-3127.2023.04.007

中图分类号:R563.9

引用信息:

[1]马璇,赵佳丽,李思琪,等.肺纤维化信号通路的研究进展[J].毒理学杂志,2023,37(04):361-364+369.DOI:10.16421/j.cnki.1002-3127.2023.04.007.

基金信息:

山东省自然基金(ZR2020MH336,ZR2015HL099); 山东省中医药科技项目(2020M077); 山东省医药卫生发展计划项目(2019WS592); 潍坊市科学技术发展计划项目(2022GX010,2022GX015); 潍坊医学院公派出国(境)访学项目经费资助

发布时间:

2023-08-25

出版时间:

2023-08-25

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