| 89 | 0 | 48 |
| 下载次数 | 被引频次 | 阅读次数 |
慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)是常见的呼吸系统疾病之一,与卷烟烟气、粉尘污染物等有害颗粒的吸入有关。由于COPD是一个慢性发展的过程,肺功能检查可能在一段时间后才能检测到明显的变化。近年来,针对COPD即生物标志物方面的研究已成为热点。本篇综述旨在归纳卷烟烟气诱发COPD发病过程中的生物标志物,包括暴露生物标志物、效应生物标志物和易感性生物标志物,并重点阐述效应标志物及其相关损伤机制。通过对现有相关COPD文献研究的归纳总结,可有助于进一步优选敏感性和特异性较高的生物标志物,为COPD生物标志物在精准医疗中的运用提供新的思路。
Abstract:[1]葛均波,徐永健,王辰.内科学[M].北京:人民卫生出版社,2019.
[2] Szalontai K,Gemes N,Furak J,et al. Chronic obstructive pulmonary disease:epidemiology,biomarkers,and paving the way to lung cancer[J]. J Clin Med,2021,10(13):2889.
[3] Mathers CD,Loncar D. Projections of global mortality and burden of disease from 2002 to 2030[J]. PLoS Med,2006,3(11):e442.
[4] Bradicich M,Schuurmans MM. Smoking status and secondhand smoke biomarkers in COPD, asthma and healthy controls[J]. ERJ Open Res,2020,6(2):00192-2019.
[5] Stockley RA,Halpin DMG,Celli BR,et al. Chronic obstructive pulmonary disease biomarkers and their interpretation[J]. Am J Respir Crit Care Med,2019,199(10):1195-1204.
[6] Mattes W,Yang X,Orr MS,et al. Biomarkers of tobacco smoke exposure[J]. Adv Clin Chem,2014,67:1-45.
[7]赵阁,王昇,余晶晶,等.新型烟草制品生物标志物研究进展[J].烟草科技,2014,43(9):84-89.
[8]赵阁,谢复炜,刘惠民.卷烟烟气生物标志物研究进展[J].中国烟草学报,2010,16(6):94-103.
[9] Traboulsi H,Cherian M,Abou Rjeili M,et al. Inhalation toxicology of vaping products and implications for pulmonary health[J]. Int J Mol Sci,2020,21(10):3495.
[10] Torres S,Merino C,Paton B,et al. Biomarkers of exposure to secondhand and thirdhand tobacco smoke:recent advances and future perspectives[J]. Int J Environ Res Public Health,2018,15(12):2693.
[11] Murphy SE. Biochemistry of nicotine metabolism and its relevance to lung cancer[J]. J Biol Chem,2021,296:100722.
[12] Marques H,Cruz-vicente P,Rosado T,et al. Recent developments in the determination of biomarkers of tobacco smoke exposure in biological specimens:A review[J]. Int J Environ Res Public Health,2021,18(4):1768.
[13] Avila-Tang E,Elf JL,Cummings KM,et al. Assessing secondhand smoke exposure with reported measures[J].Tob Control,2013,22(3):156-163.
[14] Benowitz NL, Hukkanen J, Jacob P, 3rd. Nicotine chemistry, metabolism, kinetics and biomarkers[J].Handb Exp Pharmacol,2009,192:29-60.
[15] Habibagahi A,Alderman N,Kubwabo C. A review of the analysis of biomarkers of exposure to tobacco and vaping products[J]. Anal Methods,2020,12(35):4276-4302.
[16] Kozluca H,Dural E,Karabiyikoglu G,et al. Pulmonary functional parameters and blood cotinine level in chronic obstructive pulmonary disease[J]. Tuberk Toraks,2018,66(4):317-324.
[17] Phillips B,Szostak J,Titz B,et al. A six-month systems toxicology inhalation/cessation study in Apo E(-/-)mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products,CHTP 1. 2 and THS2. 2,compared with conventional cigarettes[J]. Food Chem Toxicol,2019,126:113-141.
[18] Sakaguchi C,Nagata Y,Kikuchi A,et al. Differences in levels of biomarkers of potential harm among users of a heat-not-burn tobacco product, cigarette smokers, and never-smokers in Japan:A post-marketing observational study[J]. Nicotine Tob Res,2021,23(7):1143-1152.
[19] Flouris AD,Chorti MS,Poulianiti KP,et al. Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function[J]. Inhal Toxicol,2013,25(2):91-101.
[20] Christenson SA,Smith BM,Bafadhel M,et al. Chronic obstructive pulmonary disease[J]. The Lancet,2022,399(10342):2227-2242.
[21] Suzuki S,Asai K,Gi M,et al. Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung[J]. J Toxicol Pathol,2022,35(3):247-254.
[22] Dong T,Santos S,Yang Z,et al. Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD[J]. Analyst, 2020, 145(5):1583-1604.
[23] Wang C, Zhou J, Wang J, et al. Progress in the mechanism and targeted drug therapy for COPD[J]. Signal Transduct Target Ther,2020,5(1):248.
[24] Shyam prasad shetty B,Chaya SK,Kumar VS,et al.Inflammatory biomarkers interleukin 1 Beta(IL-1beta)and tumour necrosis factor Alpha(TNF-alpha)are differentially elevated in tobacco smoke associated COPD and biomass smoke associated COPD[J]. Toxics,2021,9(4):72.
[25] Profita M,Chiappara G,Mirabella F,et al. Effect of cilomilast(Ariflo)on TNF-alpha, IL-8, and GM-CSF release by airway cells of patients with COPD[J]. Thorax,2003,58(7):573-579.
[26] Edwards MR,Bartlett NW,Clarke D,et al. Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease[J]. Pharmacol Ther,2009,121(1):1-13.
[27] Yuan J,Liu R,Ma Y,et al. Curcumin attenuates airway inflammation and airway remolding by inhibiting NFkappa B signaling and COX-2 in cigarette smoke-induced COPD mice[J]. Inflammation,2018,41(5):1804-1814.
[28] Liang Y,Du R,Chen R,et al. Therapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat[J].Biomed Pharmacother,2021,143:112101.
[29] Watanabe T,Jono H,Han J,et al. Synergistic activation of NF-kappaB by nontypeable Haemophilus influenzae and tumor necrosis factor alpha[J]. Proc Natl Acad Sci USA,2004,101(10):3563-3568.
[30] Pelaia C,Vatrella A,Sciacqua A,et al. Role of p38-mitogen-activated protein kinase in COPD:pathobiological implications and therapeutic perspectives[J]. Expert Rev Respir Med,2020,14(5):485-491.
[31] Pratte KA,Curtis JL,Kechris K,et al. Soluble receptor for advanced glycation end products(sRAGE)as a biomarker of COPD[J]. Respir Res,2021,22(1):127.
[32] Barnes PJ. Small airway fibrosis in COPD[J]. Int J Biochem Cell Biol,2019,116:105598.
[33] Higham A,Quinn AM,Cancado JED,et al. The pathology of small airways disease in COPD:historical aspects and future directions[J]. Respir Res,2019,20(1):49.
[34] Gohy ST,Hupin C,Fregimilicka C,et al. Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition[J]. Eur Respir J,2015,45(5):1258-1272.
[35] Liu G,Philp AM,Corte T,et al. Therapeutic targets in lung tissue remodelling and fibrosis[J]. Pharmacol Ther,2021,225:107839.
[36] Mahmood MQ,Reid D,Ward C,et al. Transforming growth factor(TGF)beta(1)and Smad signalling pathways:A likely key to EMT-associated COPD pathogenesis[J]. Respirol,2017,22(1):133-140.
[37] Mahmood MQ,Walters EH,Shukla SD,et al. Betacatenin,Twist and Snail:Transcriptional regulation of EMT in smokers and COPD,and relation to airflow obstruction[J]. Sci Rep,2017,7(1):10832.
[38] Shi J,Li F,Luo M,et al. Distinct roles of Wnt/betaCatenin signaling in the pathogenesis of chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis[J].Mediators Inflamm,2017,2017:3520581.
[39] Vitenberga Z,Pilmane M,Babjoniseva A. An insight into COPD morphopathogenesis:chronic inflammation,remodeling, and antimicrobial defense[J]. Medicina(Kaunas),2019,55(8):496.
[40] Radicioni G,Ceppe A,Ford AA,et al. Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease:an analysis of the SPIROMICS cohort[J]. Lancet Respir Med,2021,9(11):1241-1254.
[41] Strzelak A,Ratajczak A,Adamiec A,et al. Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases:A mechanistic review[J]. Int J Environ Res Public Health,2018,15(5):1033.
[42] Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD[J]. Eur Respir J,2006,28(1):219-242.
[43] Antus B,Kardos Z. Oxidative stress in COPD:molecular background and clinical monitoring[J]. Curr Med Chem,2015,22(5):627-650.
[44] Chamitava L,Cazzoletti L,Ferrari M,et al. Biomarkers of oxidative stress and inflammation in chronic airway diseases[J]. Int J Mol Sci,2020,21(12):4339.
[45] Domej W,Oettl K,Renner W. Oxidative stress and free radicals in COPD--implications and relevance for treatment[J]. Int J Chron Obstruct Pulmon Dis,2014,9:1207-1224.
[46] Pandey S,Garg R,Kant S,et al. Vitamin D,C-reactive protein,and oxidative stress markers in chronic obstructive pulmonary disease[J]. Tzu Chi Med J,2021,33(1):80-86.
[47] Rajendrasozhan S, Yang SR, Edirisinghe I, et al.Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation:epigenetics in pathogenesis of COPD[J]. Antioxid Redox Signal,2008,10(4):799-811.
[48] Yu D,Liu X,Zhang G,et al. Isoliquiritigenin inhibits cigarette smoke-induced COPD by attenuating inflammation and oxidative stress via the regulation of the Nrf2 and NF-kappa B signaling pathways[J]. Front Pharmacol,2018,9:1001.
[49] Xu Y,Li J,Lin Z,et al. Isorhamnetin alleviates airway inflammation by regulating the Nrf2/Keap1 pathway in a mouse model of COPD[J]. Front Pharmacol,2022,13:860362.
[50] Li X,Shu R,Filippatos G,et al. Apoptosis in lung injury and remodeling[J]. J Appl Physiol(1985),2004,97(4):1535-1542.
[51] Demedts IK, Demoor T, Bracke KR, et al. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema[J]. Respir Res,2006,7(1):53.
[52] Gogebakan B,Bayraktar R,Ulasli M,et al. The role of bronchial epithelial cell apoptosis in the pathogenesis of COPD[J]. Mol Biol Rep,2014,41(8):5321-5327.
[53] Sauler M,Bazan IS,Lee PJ. Cell death in the lung:The apoptosis-necroptosis axis[J]. Annu Rev Physiol,2019,81:375-402.
[54] Kosacka M,Porebska I,Korzeniewska A,et al. Serum levels of apoptosis-related markers(s Fas L,TNF-a,p53and bcl-2)in COPD patients[J]. Pneumonol Alergol Pol,2016,84(1):11-15.
[55] Chen D, Gregory AD, Li X, et al. RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease[J]. JCI Insight,2021,6(12):e144689.
[56] Mizumura K,Maruoka S,Shimizu T,et al. Autophagy,selective autophagy,and necroptosis in COPD[J]. Int J Chron Obstruct Pulmon Dis,2018,13:3165-3172.
[57] Chen ZH,Lam HC,Jin Y,et al. Autophagy protein microtubule-associated protein 1 light chain-3B(LC3B)activates extrinsic apoptosis during cigarette smoke-induced emphysema[J]. Proc Natl Acad Sci U S A,2010,107(44):18880-18885.
[58] Barnes PJ. Senescence in COPD and its Comorbidities[J].Annu Rev Physiol,2017,79:517-539.
[59] Zeng Q, Zeng J. Inhibition of miR-494-3p alleviates oxidative stress-induced cell senescence and inflammation in the primary epithelial cells of COPD patients[J]. Int Immunopharmacol,2021,92:107044.
[60] Hikichi M,Mizumura K,Maruoka S,et al. Pathogenesis of chronic obstructive pulmonary disease(COPD)induced by cigarette smoke[J]. J Thorac Dis,2019,11(Suppl17):S2129-S2140.
[61] Wang S,He N,Xing H,et al. Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1alpha/NFkappa B signaling axis[J]. J Recept Signal Transduct Res,2020,40(4):388-394.
[62] Perez-Rubio G,Cordoba-Lanus E,Cupertino P,et al.Role of genetic susceptibility in nicotine addiction and chronic obstructive pulmonary disease[J]. Rev Invest Clin,2019,71(1):36-54.
[63] Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease[J]. Lancet,2012,379(9823):1341-1351.
[64] Viglio S,Bak EG,Schouten IGM,et al. Protease-specific biomarkers to analyse protease inhibitors for emphysema associated with Alpha 1-antitrypsin deficiency. An overview of current approaches[J]. Int J Mol Sci,2021,22(3):1065.
[65] Lange P,Ahmed E,Lahmar ZM,et al. Natural history and mechanisms of COPD[J]. Respirology,2021,26(4):298-321.
[66] Barnes PJ,Burney PG,Silverman EK,et al. Chronic obstructive pulmonary disease[J]. Nat Rev Dis Primers,2015,1:15076.
[67] Serban KA,Pratte KA,Bowler RP. Protein Biomarkers for COPD Outcomes[J]. Chest,2021,159(6):2244-2253.
基本信息:
DOI:10.16421/j.cnki.1002-3127.2025.05.002
中图分类号:R563.9
引用信息:
[1]刘冰清,陈莉莎,高鑫,等.卷烟烟气诱导的COPD生物标志物研究进展及其作用机制[J].毒理学杂志,2025,39(05):347-355+363.DOI:10.16421/j.cnki.1002-3127.2025.05.002.
基金信息:
北京烟草质量检测三级站科技项目(TP2022-T2)