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持久性有机污染物(persistent organic pollutants, POPs)在环境中普遍存在,并通过食物链蓄积于生物体内,对环境和人体造成较大的威胁。已有大量研究证实大部分POPs具有神经毒性,影响神经元细胞、星形胶质细胞以及小胶质细胞(microglia, MG)的功能。MG是中枢神经系统(central nervous system, CNS)固有的免疫效应细胞,在CNS的生理过程中发挥着极其重要的作用,MG介导CNS损伤和疾病的内源性免疫反应,参与一系列神经退行性疾病的发生,其活化和神经炎症为神经病理学的主要特征。本文主要概述了几种代表性的POPs,如全氟辛烷磺酸、2,3,7,8-四氯二苯并对二噁英、双酚A和多溴联苯醚,依赖MG和炎症反应诱发神经毒性的相关报道,并分析其潜在的分子机制,为将来研究POPs的神经毒性效应及机制提供一定的数据参考。
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基本信息:
DOI:10.16421/j.cnki.1002-3127.2025.01.008
中图分类号:X592;R114
引用信息:
[1]王锦,黄荣荣,张子阳等.持久性有机污染物通过小胶质细胞活化诱发神经毒性的研究进展[J].毒理学杂志,2025,39(01):68-72.DOI:10.16421/j.cnki.1002-3127.2025.01.008.
基金信息:
国家自然科学基金面上项目(82173482)